FDA-Cleared Indication

Hyperbaric Oxygen Therapy for Chronic Refractory Osteomyelitis

Chronic refractory osteomyelitis is a bone infection that persists or returns despite surgery and antibiotics. It is an FDA-cleared, UHMS-recognized indication for HBOT, used only as an adjunct to surgical and antibiotic care, where it may support infection resolution. A physician determines, with your specialists, whether HBOT is appropriate.

Physician-directed care under Dr. Rajwinder Singh Bahia, MD · Updated

The Basics

How HBOT May Support Healing in Chronic Refractory Osteomyelitis

Chronic refractory osteomyelitis is an FDA-cleared indication and a UHMS-recognized indication for hyperbaric oxygen therapy. Medicare covers it when the infection is unresponsive to conventional medical and surgical management.

Osteomyelitis is an infection in bone. When it becomes chronic, bacteria can hide in areas of dead bone and scar tissue where blood supply is poor. Antibiotics carried in the blood struggle to reach those areas, and so do the white blood cells that fight infection. The infected bone is often low in oxygen, which makes the problem worse, because several of the body's defenses depend on oxygen.

During HBOT you breathe near-100% oxygen in a pressurized chamber. Much more oxygen dissolves in your blood plasma and can diffuse into poorly supplied bone and tissue. Over a course of sessions, as an adjunct to surgery and antibiotics, HBOT may support:

  • White blood cell killing. Neutrophils use oxygen to make the compounds that kill bacteria, and they work poorly in low-oxygen tissue.
  • Antibiotic activity. Some antibiotics, such as aminoglycosides, depend on oxygen to get into bacteria.
  • New blood-vessel growth into the damaged area.
  • Bone remodeling, the ongoing work of cells that remove damaged bone and lay down new bone.

None of this replaces the removal of dead bone or a proper course of antibiotics. For more on the biology, read about oxygen and white blood cell function.

Candidacy

Who Is a Candidate?

What "refractory" means

Refractory osteomyelitis is bone infection that persists or comes back after appropriate treatment, meaning surgical debridement to remove infected and dead bone plus a proper course of antibiotics chosen from culture results. HBOT is considered for this stubborn form of the infection, not as a first step for a new one.

Where it commonly occurs

  • The diabetic foot. Deep foot ulcers often reach bone. See diabetic foot osteomyelitis.
  • Long bones after injury or surgery, such as the shin bone after a fracture or around orthopedic hardware.
  • The breastbone (sternum) after heart surgery.
  • The jaw, sometimes overlapping with osteoradionecrosis of the jaw after radiation.
  • The spine or pelvis, less commonly.

Orthopedic and infectious-disease specialists often describe chronic osteomyelitis using a staging system such as Cierny-Mader, which considers how much bone is involved and the patient's overall health. These details help the team decide on surgery, antibiotics and whether HBOT may add value.

Who is usually not a candidate

  • People with a new, uncomplicated bone infection that has not yet had standard treatment.
  • People without a surgical and antibiotic plan in place, since HBOT is only an adjunct.
  • People with an untreated collapsed lung, or other safety concerns your physician identifies. See HBOT safety.

Your physician determines whether HBOT is appropriate after reviewing your imaging, culture results, surgical history and current antibiotics. If an infection sits under a wound that won't close, see non-healing wound over infected bone. To ask whether HBOT fits your infection plan, call (369) 222-0979.

The Research

What the Evidence Shows

The honest starting point: there are no randomized controlled trials of HBOT for chronic refractory osteomyelitis. The evidence comes from case series, cohort studies and expert reviews. These are findings from published research, not promises about any individual infection.

Key evidence for HBOT in chronic refractory osteomyelitis. Findings from published research, not predicted results.
SourceYearDesignParticipantsFindingLimitation
UHMS review, Undersea and Hyperbaric Medicine2021Review of published clinical evidenceMultiple case series and cohortsAdjunctive HBOT with surgery and culture-directed antibiotics appears safe and is associated with improved infection resolution. Courses typically 20–40 sessions.No randomized trials; studies vary in patients, sites and protocols.
StatPearls, Hyperbaric Treatment of Chronic Refractory OsteomyelitisUpdated regularlyClinical reference reviewNot applicableDescribes the oxygen-dependent mechanisms and HBOT's role as an adjunct in refractory cases.Summary of existing, mostly observational, evidence.
UHMS indications (15th ed.)2023Expert reviewNot applicableRecognizes refractory osteomyelitis as an indication for HBOT.Based on the same observational evidence.

Why no randomized trials? Refractory osteomyelitis varies widely from one person to the next, and patients are usually very ill, which makes fair comparison groups hard to build. That does not prove HBOT works, and it does not prove it doesn't. It means your physician should explain the evidence plainly and set clear goals for a course, with regular review.

Your Plan

What a Course Looks Like

At Generations Wellness, care is directed by Dr. Rajwinder Singh Bahia, MD. Sessions take place in hard-shell monoplace chambers, each for one person, where you breathe medical-grade oxygen at a physician-prescribed pressure while staff stay in communication with you.

  • Number of sessions: typically 20 to 40.
  • Frequency: usually once a day, five days a week.
  • Session length: about 90 to 120 minutes including pressurization and depressurization.
  • Pressure: commonly 2.0 to 2.5 ATA, as prescribed by your physician.
  • Timing: ideally started soon after surgical debridement, while culture-directed antibiotics continue.
  • Follow-up: your specialists track progress with exams, lab tests and imaging.

If you are on IV antibiotics through a PICC line, tell us. The line and any dressings are reviewed for chamber safety. To picture a typical visit, read what to expect at your first session.

Safety

Risks and Contraindications

HBOT is generally well tolerated under physician supervision, but it has side effects. The most common is ear or sinus pressure (barotrauma). Others include temporary nearsightedness that usually resolves after the course, tiredness and confinement anxiety. People with diabetes can see blood sugar drop during sessions.

Serious complications are rare. Oxygen-toxicity seizures occur in roughly 1 in 5,000 to 10,000 treatments. The only absolute contraindication is an untreated collapsed lung. Some medications need review, including disulfiram and certain chemotherapy drugs, as do lung conditions, seizure disorders, recent ear surgery and implanted devices. Read more in HBOT safety and contraindications.

Paying for Care

Cost and Insurance for Osteomyelitis

Generations Wellness currently offers HBOT on a self-pay basis. We do not bill insurance, Medicare or Medi-Cal today while we work toward insurance contracts, and we say so plainly before you begin.

In general, this is one of the indications insurance may cover. Original Medicare's NCD 20.29 covers "chronic refractory osteomyelitis, unresponsive to conventional medical and surgical management." Your records usually need to show that surgery and antibiotics have already been tried. At facilities that bill Medicare, patients typically pay the Part B deductible ($283 in 2026) and then 20% coinsurance, which published estimates put at roughly $90 to $115 per session. Commercial and Medicare Advantage plans commonly require prior authorization.

Published national self-pay ranges for medical-grade HBOT at independent centers run about $150 to $450 per session, and a 20- to 40-session course adds up. These are ranges, not quotes. We review pricing for your physician-recommended plan clearly at your consultation. If you likely qualify for coverage, ask us and we'll explain your options honestly. See Medicare coverage for refractory osteomyelitis and HBOT cost per session and per course.

Coordinated Care

Working With Your Infectious-Disease, Orthopedic or Podiatry Team

Chronic bone infection is managed by a team: an infectious-disease physician choosing antibiotics, a surgeon removing infected bone and managing hardware, and often a podiatrist, wound clinic or home infusion service. In Modesto and the wider Central Valley, that care may be based at a hospital, a specialty practice or a community clinic.

HBOT, when appropriate, is added to that team's plan. With your permission, our physician shares updates with your specialists so antibiotic timing, surgery dates and HBOT sessions fit together. Physicians can refer a patient or call to discuss a case.

Important

A physician assessment is required before beginning HBOT at Generations Wellness. HBOT complements, and never replaces, the treatment prescribed by your doctors. High fever, chills or rapidly worsening pain or swelling needs prompt medical care.

Questions

Osteomyelitis and HBOT: Frequently Asked Questions

Is hyperbaric oxygen therapy used for osteomyelitis?

For chronic refractory osteomyelitis, HBOT is an FDA-cleared adjunct to surgery and antibiotics. Reviews report improved infection resolution, though no randomized trials exist.

What does "refractory" mean?

Bone infection that persists or returns after appropriate surgical debridement and a proper course of antibiotics.

How many HBOT sessions are needed for osteomyelitis?

Typically 20 to 40 daily sessions, ideally started soon after debridement and alongside culture-directed antibiotics.

Can HBOT replace antibiotics or surgery?

No. It is used only in addition to them.

Do you bill Medicare for osteomyelitis?

Not currently. Generations Wellness offers HBOT on a self-pay basis today. Medicare can cover refractory osteomyelitis at facilities that bill it, and we'll explain your options honestly.

Sources

  1. Undersea and Hyperbaric Medical Society. Hyperbaric oxygen for refractory osteomyelitis. Undersea and Hyperbaric Medicine. 2021;48(3). uhms.org
  2. StatPearls. Hyperbaric Treatment of Chronic Refractory Osteomyelitis. ncbi.nlm.nih.gov
  3. Centers for Medicare & Medicaid Services. National Coverage Determination 20.29, Hyperbaric Oxygen Therapy. cms.gov
  4. Undersea and Hyperbaric Medical Society. Hyperbaric Oxygen Therapy Indications. uhms.org
  5. U.S. Food and Drug Administration. Hyperbaric Oxygen Therapy: Get the Facts. fda.gov
  6. StatPearls. Hyperbaric Complications. ncbi.nlm.nih.gov
  7. MedlinePlus. Osteomyelitis. medlineplus.gov

This page is educational and not medical advice. Study results describe published research, not expected outcomes. A physician assessment is required before HBOT. See our full medical disclaimer.

Your Next Step

Begin With a Physician Assessment

Every course starts with an honest conversation and a physician assessment. No pressure, no obligation.

Prefer to talk? (369) 222-0979